The only other use of "lech-lecha" in Genesis -- the Akedah's opening command, closing the bracket this verse opens on Abraham's entire story.
Hebrews 11:8 reads this exact call - leave everything, go to a place not yet named - as the essence of Abraham's faith: he went, not knowing where he was going.
Now Yahweh said to Abram, “Leave your country, and your relatives, and your father’s house, and go to the land that I will show you.
He said, “Now take your son, your only son, whom you love, even Isaac, and go into the land of Moriah. Offer him there as a burnt offering on one of the mountains which I will tell you of.”
By faith, Abraham, when he was called, obeyed to go out to the place which he was to receive for an inheritance. He went out, not knowing where he went.
The Hebrew phrase translated "go" here, lech-lecha, is unusual — it means something closer to "get yourself going," and it appears in exactly one other place in the entire Bible: God's command to Abraham to take Isaac to Moriah (22:2). Those two commands bookend Abraham's whole story — the call that starts everything and the test that culminates it use identical, rare wording. Whatever this chapter is setting in motion, Genesis wants the ending read against this beginning.